Pengaruh Ekstrak Benalu Teh (Scurrula oortiana) sebagai Imuno-Modulator pada Infeksi Marek’s Disease Virus Onkogenik
Abstract
ABSTRACT: Marek’s disease virus (MDV) is one of oncogenic herpesvirus. It causes immunosupresion and cancer in
chicken. Several plants produce bioactive compounds which are very useful for treatment of many disease, especially
hiperproliveration and virus infection. This study was aimed to find out mechanism of immuno-modulatory capacity in
layer commercial chicken administered orally with extract of tea parasite (Scurrula oortiana) in dose of 10 mg/kg BW through drinking water, then the chicken were infected by intraperitoneal oncogenic MDV in dose of 1,0 x103 TCID50. The
study used 60 layer commercial day old chicks (DOC) divided into four group treatments. The treatments were group A
(administered S. oortiana extract and without MDV infection), B (neither S. oortiana nor MDV infection), C (administered
S. oortiana extract and with MDV infection), and D (without administered S. oortiana extract, but with MDV infection).
Results showed that MDV oncogenic caused immunosupresion at a day post infection (p.i) and recovery to be normal based
on relative weight of bursa Fabricius and thymus at 40 days p.i. The extract of S. oortiana had a capability as an
immunomodulator indicated by the increase of relative weight of bursa Fabricius and thymus at day 20 days p.i.
chicken. Several plants produce bioactive compounds which are very useful for treatment of many disease, especially
hiperproliveration and virus infection. This study was aimed to find out mechanism of immuno-modulatory capacity in
layer commercial chicken administered orally with extract of tea parasite (Scurrula oortiana) in dose of 10 mg/kg BW through drinking water, then the chicken were infected by intraperitoneal oncogenic MDV in dose of 1,0 x103 TCID50. The
study used 60 layer commercial day old chicks (DOC) divided into four group treatments. The treatments were group A
(administered S. oortiana extract and without MDV infection), B (neither S. oortiana nor MDV infection), C (administered
S. oortiana extract and with MDV infection), and D (without administered S. oortiana extract, but with MDV infection).
Results showed that MDV oncogenic caused immunosupresion at a day post infection (p.i) and recovery to be normal based
on relative weight of bursa Fabricius and thymus at 40 days p.i. The extract of S. oortiana had a capability as an
immunomodulator indicated by the increase of relative weight of bursa Fabricius and thymus at day 20 days p.i.
Keywords
Marek’s disease virus (MDV), Scurrula oortiana, immuno-modulator